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Roasted Brussels Sprouts and Butternut Squash (Easy Holiday Side!)

A beautiful plate of a homemade, elegant, and colorful Roasted Brussels Sprouts and Butternut Squash, being served with a thick slice of a roasted turkey at a Thanksgiving dinner.

A simple and vibrant recipe for roasted Brussels sprouts and butternut squash, perfect as a fall or holiday side dish. This one-pan (or two-pan) meal features chunks of butternut squash, Brussels sprouts, and red onions tossed with olive oil and chili powder, then roasted until tender and caramelized. The finished vegetables are transferred to a serving dish and tossed with a sweet and tangy pomegranate molasses and a sprinkle of fresh pomegranate seeds for a pop of color and flavor.

Ingredients

  • 1 large butternut squash (about 2 1/2 pounds)
  • 2 pounds Brussels sprouts
  • 4 red onions, quartered
  • 1/2 cup olive oil
  • Kosher salt and freshly ground pepper
  • 2 teaspoons chili powder
  • 1/4 cup pomegranate molasses
  • 1 cup pomegranate seeds

Instructions

  1. Preheat the oven to 400°F.
  2. Prepare the butternut squash by peeling it, cutting it in half lengthwise, removing the seeds, and chopping it into small pieces.
  3. Trim the Brussels sprouts and cut them in half if desired. Break the quartered onions apart into wedges.
  4. Divide the squash, Brussels sprouts, and onions between two baking sheets.
  5. Drizzle the vegetables with the olive oil. Season with salt and pepper, sprinkle with the chili powder, and toss to coat everything evenly.
  6. Roast for 30 to 35 minutes, or until the vegetables are tender and browned.
  7. Transfer the roasted vegetables to a large serving dish.
  8. Drizzle with the pomegranate molasses and sprinkle with the pomegranate seeds. Toss to combine and serve immediately.

Notes

  • This is a very easy and healthy sheet pan side dish, perfect for a large gathering or a holiday like Thanksgiving or Christmas.
  • Using two baking sheets is a key step that ensures the vegetables have enough space to roast and caramelize rather than steam.
  • The combination of sweet roasted vegetables with the tart pomegranate molasses creates a delicious, balanced flavor profile.
  • This dish is naturally vegan and gluten-free.